Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis

Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis.

The growth of hierarchical blood vessel networks occurs by angiogenesis. During this process, new vessel growth is accompanied by the removal of redundant vessel segments by selective vessel regression ('pruning') and a reduction in endothelial cell (EC) density in order to establish an efficient, hierarchical network. EC apoptosis has long been recognised for its association with angiogenesis,...

Endothelial Cell Apoptosis in Angiogenesis and Vessel Regression

The programmed form of cell death (apoptosis) is essential for normal development of multicellular organisms. In the past few years, compelling evidence accumulated that dysregulation of apoptosis can lead to embryonal death and is involved in the pathophysiology of various inflammatory and degenerative diseases. Specifically, the occurrence of endothelial cell apoptosis has deleterious effects...

Blood vessel diameter Measurement on retinal Image

Accurate measurement of vessel diameters on retinal images plays an important part in diagnosing cardiovascular diseases and early signs of certain systemic diseases, such as diabetes and hypertension. In this study we develop new method based on computer aided to determine the width of retinal blood vessels by analysing the color fundus image. Retinal vessel diameter was measured based on bloo...

Continuous retinal vessel diameter measurements: the future in retinal vessel assessment?

PURPOSE To establish an alternative method, sequential and diameter response analysis (SDRA), to determine dynamic retinal vessel responses and their time course in serial stimulation compared with the established method of averaged diameter responses and standard static assessment. METHODS SDRA focuses on individual time and diameter responses, taking into account the fluctuation in baseline...

Stimulates Vessel Density and Vessel Diameter Differently in Angiogenesis and Lymphangiogenesis